Blood plasma fractionation
OwnerJohn G. Wattinventor
Life of this patent
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Abstract
A liquid containing plasma proteins in solution and a liquid precipitant are intermixed by projecting through space a pair of convergent solid jets of respectively the solution and the precipitant so that the jets combine and the liquids thereof intermix, plasma protein being precipitated instantaneously on intermixing of the liquids and being subsequently separated from the liquid mixture; by creating miniature jets, especially jets with diameters in the range 0.5mm to 2mm, the intermixing can be effected in a small confined space whereof the temperature can be closely controlled to prevent denaturation of the mixture, intimate intermixing of the liquids can be attained practically instantaneously in said space, and jet flow can be transformed to film flow without denaturation of the mixture by foaming or turbulence.
Claims7
A method for fractionating a solution containing a plurality of plasma proteins, which comprises:
- continuously converging a jet stream of a plasma containing a protein fraction to be precipitated, said fraction comprising globulin, and a jet stream of a liquid protein precipitant onto a temperature controlled surface such that admixture of said plasma and protein precipitant occurs substantially simultaneously upon impingement of said jet streams upon said temperature controlled surface so that precipitation of said protein fraction comprising globulin is initiated without significant foaming and turbulence of said mixture which denatures said protein fraction and such that when the precipitation reaction is exothermic, the resultant increase in temperature does not result in denaturation of said protein fraction;
- and collecting the protein fraction which precipitates from said plasma.
Dependencies are inferred from the claim text.