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US 4,066,834 AGranted
Cycloalkenyl analogues of prostaglandins E
AssigneeMiles Laboratories, Inc.
InventorsWarren Dexter Woessner, William Gerard Biddlecom, Henry Clifford Arndt, George Peter Peruzzotti, Charles John Sih
Life of this patent
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Abstract
Analogues of prostaglandins A, E, and F in which the C.sub.13 -C.sub.20 chain of the natural prostaglandins is replaced by a cycloalkenyl or a hydroxycycloalkenyl moiety such that vinylene radical and the hydroxyl group of the ring respectively retain their natural sequential positions at C.sub.13 -C.sub.14 and C.sub.15, inhibit aggregation of platelets in vitro and exhibit useful cardiovascular activity in vivo.
Claims19
A compound having the formula, ##STR28## in which:
- A is selected from the group consisting of methylene, ethylene, 1,1-dimethylethylene, trimethylene, tetramethylene, pentamethylene, hexamethylene, heptamethylene, and octamethylene;
- E is selected from the group consisting of methylene, .alpha.-hydroxymethylene, and .beta.-hydroxymethylene;
- G is selected from the group consisting of hydrogen and methyl;
- J is selected from the group consisting of methylene, .alpha.-hydroxymethylene, and .beta.-hydroxymethylene;
- Q is selected from the group consisting of ethylene and vinylene;
- and
- R is selected from the group consisting of carboxyl, carbomethoxy, and carbethoxy.
4 more elements
Dependencies are inferred from the claim text.