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US 4,066,827 AGranted
Process for producing a polyion complex having a nucleic acid base
AssigneeToyo Soda Manufacturing Co., Ltd.
InventorsToru Seita, Akihiko Shimizu, Yujiro Kosaka
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Abstract
A polyion complex is produced by reacting a weak acid type or a strong acid type polyanion polymer with a nucleic acid base-containing polycation polymer.
Claims9
A process for producing a polyion complex which comprises reacting a polyanion polyacrylic acid or polymethacrylic acid polymer, or alkali metal salts thereof, with a nucleic acid base-containing polycation polymer having the unit formula ##STR18## wherein R.sub.1 is a hydrogen atom or a C.sub.1-4 alkyl group;
- R.sub.2 and R.sub.3 are each a C.sub.1-10 hydrocarbon group;
- R.sub.4 is a hydrogen atom or a methyl group;
- R.sub.5 is a C.sub.1-16 alkyl group;
- R.sub.6 and R.sub.7 are each a C.sub.1-4 alkyl group;
- M is a vinyl monomer;
- x is 0-450,000;
- Z is a halogen atom or an hydroxyl group;
- y is 0 or 1;
- n is an integer higher than 10;
- X is adenine, thymine, cytosine, uracil or a derivative thereof in which a purine nucleus is bonded to the 9-position and a pyrimidine nucleus is bonded to the 1-position.
7 more elements
Dependencies are inferred from the claim text.