Tropone derivatives
AssigneeAyerst McKenna and Harrison Ltd.
InventorsJehan F. Bagli, Tibor Bogri
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Abstract
Tropone derivatives substituted with an amino-derivative of oxalic acid or acetic acid are disclosed. In addition, the tropone nucleus can be optionally further substituted. The foregoing compounds are useful for preventing or treating allergic conditions in a mammal. Methods for the preparation and use of the compounds are disclosed.
Claims6
A compound of formula I ##STR5## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different selected from the group consisting of hydrogen;
- halo, trifluoromethyl;
- lower alkoxy;
- lower alkyl;
- phenyl;
- hydroxy;
- phenoxy;
- mercapto;
- NR.sup.7 R.sup.8 wherein each of R.sup.7 and R.sup.8 is hydrogen or lower alkyl;
- and a radical of formula Y-CR.sup.9 R.sup.10 -COOR.sup.11 wherein Y is NR.sup.12 wherein R.sup.12 is hydrogen or lower alkyl, R.sup.9 and R.sup.10 together are oxo and R.sup.11 is hydrogen or lower alkyl, with the proviso that one, two or three of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 must be a radical of formula Y-CR.sup.9 R.sup.10 -COOR.sup.11 wherein Y, R.sup.9, R.sup.10 and R.sup.11 are as defined in each instance herein;
- and with the additional proviso that when R.sup.1 and/or R.sup.4 is a radical of formula Y-CR.sup.9 R.sup.10 -COOR.sup.11 wherein Y is NR.sup.12 wherein R.sup.12 is as defined herein, R.sup.9 and R.sup.10 together are oxo and R.sup.11 is as defined herein, then at least one of R.sup.2, R.sup.3, R.sup.5 and R.sup.6 must be a radical of formula Y-CR.sup.9 R.sup.10 -COOR.sup.11 wherein Y, R.sup.9, R.sup.10 and R.sup.11 are as defined in each instance herein;
- or a therapeutically acceptable salt thereof.
A compound of formula I ##STR6## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different selected from the group consisting of hydrogen or a radical of formula Y-CR.sup.9 R.sup.10 -COOR.sup.11 wherein Y is NR.sup.12 wherein R.sup.12 is hydrogen or lower alkyl, R.sup.9 and R.sup.10 together are oxo and R.sup.11 is hydrogen or lower alkyl, with the proviso that one, two or three of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 must be a radical of formula Y-CR.sup.9 R.sup.10 -COOR.sup.11 wherein Y, R.sup.9, R.sup.10 and R.sup.11 are as defined in each instance herein;
- and with the additional proviso that when R.sup.1 and/or R.sup.4 is a radical of formula Y-CR.sup.9 R.sup.10 -COOR.sup.11 wherein Y is NR.sup.12 wherein R.sup.12 is as defined herein, R.sup.9 and R.sup.10 together are oxo and R.sup.11 is as defined herein, then at least one of R.sup.2, R.sup.3, R.sup.5 and R.sup.6 must be a radical of formula Y-CR.sup.9 R.sup.10 -COOR.sup.11 wherein Y, R.sup.9, R.sup.10 and R.sup.11 are as defined in each instance herein;
- or a therapeutically acceptable salt thereof.
A compound of formula I ##STR7## in which each of R.sup.1 and R.sup.6 is a radical of formula Y-CR.sup.9 R.sup.10 -COOR.sup.11 wherein Y is NR.sup.12 wherein R.sup.12 is hydrogen or lower alkyl, R.sup.9 and R.sup.10 together are oxo and R.sup.11 is hydrogen or lower alkyl and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are hydrogen;
- or a therapeutically acceptable salt thereof.
Dependencies are inferred from the claim text.