Tetrahydroimidazole compounds useful as pharmaceuticals
AssigneeCiba-Geigy Corporation
InventorsKuppuswamy Nagarajan, Vishwa Prakash Arya, Thomas George
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Abstract
The present invention relates to new imidazoles, especially of 4- or 5-nitro-imidazoles, substituted by tetrahydroimidazoles which may be substituted and to such compounds which are valuable chemotherapeutica in the treatment of gram-negative bacteria, protozoa and worms.
Claims13
A compound of the formula ##STR13## wherein one of the groups R.sub.1 and R.sub.2 is a hydrogen or lower alkyl and the other a nitro group, R.sub.3 is a lower alkyl, hydroxy-lower alkyl, lower-alkoxy-lower-alkyl, lower-alkylsulphonyl-lower-alkyl or amino-lower-alkyl, R.sub.4 is an oxo or thioxo group, X is a sulphinyl or sulphonyl group and R.sub.5 is a lower alkyl, aryl, amino, alkylamino or diloweralkylamino group and alk is 1,2-ethylene, their pharmaceutically acceptable salts or N-oxides.
1-N-Ethylsulphonyl-2-oxo-3-[1-methyl-5-nitroimidazolyl-(2)]-tetrahyd roimidazole or its pharmaceutically acceptable salts.
1-(Methylsulphonyl)-2-oxo-3-[1-methyl-5-nitro-imid azolyl-(2)]-tetrahydroimidazole, or its pharmaceutically acceptable salts.
1-(Methylsulphonyl)-2-oxo-3-[1-methyl-5-nitroimidazolyl-(2)]-4-methyl-t etrahydroimidazole or its pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.