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US 4,066,761 AGranted
7-Acyl-3-(ureidoalkyl substituted tetrazolylthiomethyl)cephalosporins
AssigneeSmithKline Corporation
InventorDavid A. Berges
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Abstract
The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have anti-bacterial activity.
Claims9
A compound of the formula:
- ##STR8## in which:
- R.sup.1 is an acyl group of the formula:
- ##STR9## where:
- Y is cyano, aminomethylphenyl, sydnone, thienyl, pyridone or tetrazolyl;
- and
- n is two to five,
- or a non-toxic pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.