Therapeutic compositions of 1,3-bis(2-carboxychromon-5-yloxyl)propan-2-ol and aspirin or indomethacin
AssigneeFisons Limited
InventorsThomas Samuel Campbell Orr, David Edward Hall, John Mann
Life of this patent
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Abstract
There is described a pharmaceutical mixture comprising 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol, or a pharmaceutically acceptable salt thereof, and aspirin or indomethacin. The mixture causes less gastrointestinal adverse effects than aspirin or indomethacin on their own.
Claims14
A pharmaceutical composition comprising 1,3-bis-(2-carboxy-chromon-5-yloxy)propan-2-ol, or a pharmaceutically acceptable salt thereof, as active ingredient, in combination with about 0.12 to 6000 parts by weight of aspirin or about 0.02 to 1000 parts by weight of indomethacin to each part by weight of active ingredient.
A pharmaceutical package comprising at least one unit dose of 1,3-bis-(2-carboxychromon-5-yloxy)propan-2-ol, or a pharmaceutically acceptable salt thereof, as active ingredient, and at least one unit dose of indomethacin or aspirin.
A method of inhibiting adverse gastrointestinal effects created in a mammal by administration of aspirin or indomethacin, which method comprises administering to said mammal an effective amount of 1,3-bis-(2-carboxy-chromon-5-yloxy)propan-2-ol or a pharmaceutically acceptable salt thereof, sequentially or substantially simultaneously with the administration of said aspirin or indomethacin.
Dependencies are inferred from the claim text.