Phenylaminoethanol derivatives for treating hypertension
AssigneeAllen & Hanburys Limited
InventorsLawrence Henry Charles Lunts, David Trevor Collin
Life of this patent
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Abstract
Compounds of the formula: ##STR1## and physiologically acceptable acid addition salts thereof, in which R.sup.1 is A. an arylalkyl group, the alkyl portion of which contains from 1 to 6 carbon atoms and the aryl portion of which may be substituted by one or more alkoxy groups or hydroxy groups; or B. an aryloxyalkyl group, the alkyl portion of which contains from 1 to 6 carbon atoms, and the aryloxy portion of which is substituted with one or more alkoxy or hydroxy groups. These compounds have a blacking action on both .alpha.- and .beta.-adrenergic receptors and are useful in treating hypertension. Processes for the production of these compounds and pharmaceutical compositions containing them are also provided.
Claims10
A pharmaceutical composition for the treatment of hypertension, comprising as active ingredient, an effective amount of 5-[1-hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl]salicylamide or a physiologically acceptable acid addition salt thereof in association with a non-toxic pharmaceutically acceptable carrier.
A method of treating a human patient suffering from hypertension by blocking both .alpha.- and .beta.-adrenergic receptors in the patient, characterized in that there is administered orally, by suppository or by injection, an effective amount of a compound having both .alpha.- and .beta.-blocking activity, which compound is 5-[1-hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide or a physiologically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.