Back to results
US 4,066,754 AGranted
Slow release bolus
AssigneeRalston Purina Company
InventorShih-Toon Chou
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeRalston Purina Company
InventorShih-Toon Chou
Estimating the term…
A composition for slowly releasing a veterinary medicament in a ruminant animal is described. The composition comprises a water-insoluble and water resistant binder a therapeutically active substance and a critical water-insoluble controlled release agent. The process of the invention includes the steps of adding a solution of a water-insoluble binder dissolved in an organic solvent to a mixture of a therapeutically active substance and a water-insoluble dense filler, stirring the mixture until free flowing granules are formed, drying the granules, blending the dried granules with a lubricant and a water insoluble controlled release agent and compressing the mixture into convenient veterinary dosage forms. When the veterinary composition is orally administered to a ruminant animal it remains in the animal's body for a desired period of time and the therapeutically active substance contained therein is released in a predictable and controllable pattern.
An improved method of preparing a sustained release veterinary bolus for ruminant animals having a therapeutically active substance, filler material, binder and lubricant wherein the improvement comprises forming the binder by combining an effective amount of zein and an organic solvent, mixing the binder with the therapeutically active substance and filler material to granulate the mixture, drying the mixture, adding a lubricant, blending the dried mixture with an effective amount of zein to insure sustained release of the therapeutically active substance and forming a bolus of sufficient density that will remain in a ruminant animal to release the therapeutically active substance for a period of time up to 15 days in a predictable, controllable pattern.
An improved method of preparing a sustained release veterinary bolus for ruminant animals comprising:
A solid, sustained release veterinary bolus for ruminant animals comprising (1) from about 1 to about 80% by weight of a therapeutically active substance, (2) from about 10 to about 95% by weight of a filler material, (3) from about 0.1 to about 0.5% by weight of a lubricant and (4) from about 6 to about 35% by weight of zein, said veterinary bolus being characterized by containing a binder comprising about 5 to about 25% by weight of zein of foregoing step 4 and a disintegrating agent comprising from about 1 to about 10% by weight of zein.
A solid sustained release veterinary bolus for ruminant animals comprising a therapeutically active substance, filler material, binder, lubricant and disintegrating agent with an effective amount of zein utilized in said binder and disintegrating agent to provide sustained release of said therapeutically active substance for a period of time up to 15 days in a predictable controllable pattern while simultaneously protecting the essential microorganisms normally responsible for digestive fermentation within said ruminant animal from being adversely affected by said therapeutically active substance.
Dependencies are inferred from the claim text.