X-ray contrast agents
AssigneeMallinckrodt Inc.
InventorMills T. Kneller
Life of this patent
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Abstract
3-Acetamido-5-(4,4-bishydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid, 3-acetamido-5-(4-methyl-4-hydroxymethyl-2-oxazolinyl)-2,4,6-triiodob enzoic acid, analogous compounds and salts and esters thereof are useful as X-ray contrast agents. The corresponding acyl halides are useful as intermediates.
Claims12
A compound of the formula:
- ##STR5## wherein R.sub.1 is hydroxymethyl and R.sub.2 is selected from the group consisting of hydroxymethyl and a lower alkyl group containing between 1 and 4 carbon atoms, and esters thereof with lower alkanols, salts thereof with pharmaceutically acceptable cations, and acyl halides thereof.
An X-ray contrast medium comprising an aqueous solution of a salt of a compound selected from the group consisting of 3-acetamido-5-(4,4-bishydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid and 3-acetamido-5-(4-methyl-4-hydroxymethyl-2-oxazolinyl)-2,4,6-triiodobenzoic acid with at least one pharmaceutically acceptable cation.
Dependencies are inferred from the claim text.