Tc-99m sulfur colloid radiopharmaceuticals
AssigneeMedi-Physics, Inc.
InventorMichael David Garrett
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Abstract
A Tc-99m stannous sulfur colloid radiopharmaceutical having simplicity of formulation, improved stability and desirable small particle size as well as a method of preparation therefor are described. Also provided is a reagent suitable for the preparation of such radiopharmaceutical by the addition thereto of technetium-99m pertechnetate.
Claims7
A method for the preparation of a stannous sulfur colloid reagent suitable for the preparation of a size-stabilized Tc-99m-labeled radiopharmaceutical which comprises:
- a. adding a sufficient quantity of a 1 molar colloid of stannous chloride in sterile, pyrogen-free water to a predetermined quantity of distilled water to achieve a stannous chloride concentration in the final reagent of between about 0.5 and about 2.0 millimoles;
- b. adding to the mixture of step a) a sufficient quantity of 5% by weight aqueous solution of gelatin to achieve a gelatin concentration in the final reagent of between about 0.05% by weight and about 1.0% by weight;
- c. treating the mixture of step b) with hydrogen sulfide gas;
- d. purging the reagent formed in c) with nitrogen gas;
- e. filtering said reagent through a filter having openings of 0.45 micron;
- and
- f. aseptically sealing said reagent in a nitrogen-purged ampul.
A packaged reagent for preparing size-stabilized sulfur colloid consisting of an aqueous colloid of stannous sulfide additionally containing from about 0.05% by weight to about 1.0% by weight gelatin, based on the total reagent, aseptically enclosed in a nitrogen-purged ampule.
Dependencies are inferred from the claim text.