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US 4,066,700 AGranted
2-Decarboxy-2-hydroxymethyl-3,7-inter-m-phenylene-3-oxa-PGD.sub.1 compounds
AssigneeThe Upjohn Company
InventorNorman A. Neslon
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Abstract
This invention comprises certain analogs of the prostaglandins in which the C-1 carboxyl is replaced by a primary alcohol. Also provided in this invention, are novel chemical processes useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.
Claims22
A prostaglandin analog of the formula ##STR1## wherein Y is trans--CH.dbd.CH--;
- wherein M.sub.1 is ##STR2## wherein R.sub.5 is hydrogen or methyl;
- Wherein
- L.sub.1 is ##STR3## or a mixture of ##STR4## and ##STR5## wherein R.sub.3 and R.sub.4 are hydrogen, methyl, or fluoro, the same or different, with the proviso that one of R.sub.3 and
- R.sub.4 is methyl only when the other is hydrogen or methyl;
- Wherein g is one, 2, or 3;
- and
- Wherein m is one to 5, inclusive.
4 more elements
Dependencies are inferred from the claim text.