Process for the manufacture of organic hydrazines
AssigneeHoechst Aktiengesellschaft
InventorHermann Clasen
Life of this patent
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Abstract
Organic substituted hydrazines are prepared by introducing chloramine optionally carrying one or two alkyl groups into an intensely agitated or finely divided liquid, substantially anhydrous phase of a liquid primary or secondary amine or a solution of a primary or secondary amine in an inert solvent. Especially phenylhydrazine can be obtained in a very good yield from chloramine and aniline. The organic substituted hydrazines are important intermediates for syntheses, especially of pharmaceutical products.
Claims13
A process for the preparation of organic hydrazines which comprises introducing a gaseous chloramine selected from the group consisting of chloramine, monoalkyl chloramine and dialkyl chloramine into a substantially anhydrous liquid phase organic amine selected from the group consisting of primary amine and secondary amine while intensely agitating the liquid phase during the addition of the chloramine and selectively reacting the chloramine with the organic amine to form the corresponding organic hydrazine.
A process for the preparation of organic hydrazines which comprises contacting, under conditions of intense liquid agitation, a gaseous chloramine selected from the group consisting of chloramine, monoalkyl chloramine and dialkyl chloramine with a substantially anhydrous organic amine selected from the group consisting of primary amine and secondary amine in finely divided liquid phase and selectively reacting the chloramine with the organic amine to form the corresponding organic hydrazine.
A process of the preparation of organic hydrazines which comprises introducing a gaseous chloramine selected from the group consisting of chloramine, monoalkyl chloramine and dialkyl chloramine into a substantially anhydrous liquid phase organic amine selected from the group consisting of primary and secondary amine and selectively reacting the chloramine with the organic amine at a liquid phase temperature between about room temperature and 150.degree. C and a gas phase temperature between about room temperature and about 300.degree. C to form the corresponding organic hydrazine while intensely agitating the liquid phase during the addition of the chloramine to reduce contact of organic hydrazine product with chloramine reactant and maintaining the content of the organic hydrazine in the reaction mixture below about 6% by weight of the reaction mixture.
A process for the preparation of organic hydrazines which comprises contacting a gaseous chloramine selected from the group consisting of chloramine, monoalkyl chloramine and dialkyl chloramine with a substantially anhydrous organic amine selected from the group consisting of primary amine and secondary amine in finely divided liquid phase and selectively reacting the chloramine with the organic amine at a liquid phase temperature between about room temperature to about 150.degree. C and a gas phase temperature between about room temperature and about 300.degree. C to form the corresponding organic hydrazine while intensely agitating the liquid phase during the addition of the chloramine to reduce contact of organic hydrazine product with the chloramine reactant and maintaining the content of the organic hydrazine in the reaction mixture below about 6% by weight of the reaction mixture.
Dependencies are inferred from the claim text.