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US 4,066,695 AGranted
Thiourea derivatives
AssigneeHoffmann-La Roche Inc.
InventorsMichael Robert Cohen, Richard Wightman Kierstead, Jefferson Wright Tilley
Life of this patent
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Abstract
Antihypertensively active thiourea derivatives of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter described, as well as a method of using a compound of the formula ##STR2## wherein R.sub.1 ', R.sub.2 ', R.sub.3 and X are as previously described, or a compound of formula II as an anti-hypertensive agent, is described.
Claims3
A compound of the formula ##STR16## wherein R is lower alkyl;
- R.sub.1 and R.sub.2, independently, are halogen;
- R.sub.3 is amino;
- and addition salts thereof with pharmaceutically acceptable acids.
Dependencies are inferred from the claim text.