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AssigneeRyuichi Sato
InventorsRyuichi Sato, Akira Ishikawa, Yukihito Ishida, Hiroshi Sato, Setsuo Tomisawa, Shigeshi Toyoshima, Shiro Ikegami
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Novel pharmacologically important organic germanium compounds (3-hydroxygermyl propionic acid salts) represented by the formula ##STR1## WHEREIN Met is a monovalent cation selected from the group consisting of Na, K, NH.sub.4, and NH.sub.2 (CH.sub.3).sub.2, or divalent cation selected from the group consisting of Ca and Mg, and wherein x is 1 when Met is a monovalent cation and x is 2 when Met is a divalent cation. These compounds possess valuable therapeutic properties for treating such physiological abnormalities as psychiatric and neurological disorders, metabolic disorder, cardivascular disorder, disorder of digestive organs, skin disease, allergic disease, Kidney dysfunction, hepatic dysfunction, obstetric and pediatric diseases, etc., and the process for preparing thereof.
A compound of the formula ##STR4## wherein Met is a monovalent cation selected from the group consisting of Na, K, NH.sub.4, and NH.sub.2 (CH.sub.3).sub.2, or a divalent cation selected from the group consisting of Ca and Mg, and wherein x is 1 when Met is a monovalent cation and x is 2 when Met is a divalent cation.
A process for preparing the compound of claim 1, which process comprises reacting trichlorogermanium with acrylic acid to thereby obtain 3-trichlorogermyl propionic acid of the formula ##STR5## hydrolyzing said acid with caustic alkali solution followed by acidification to thereby obtain 3-germylpropionic acid oxide of the formula
Dependencies are inferred from the claim text.