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US 4,066,675 AGranted
9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins and processes
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., John B. Bicking, Robert L. Smith
Life of this patent
Estimating the term…
Abstract
This invention relates to 9-thia-, 9-oxothia, and 9-dioxothia-11,12-seco-prostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful for the treatment of skin diseases such as psoriasis, for the prevention of thrombus formation, in stimulating the production of growth hormone in intact animals, and as regulators of the immune response.
Claims11
The compound of the formula ##STR48## wherein R is carboxy, a carboxy salt, or a carboxy ester;
- ;p1 A is methylene;
- Y is selected from the group consisting of ethylene, vinylene, and ethynylene;
- R.sup.1 is selected from the group consisting of methyl, ethyl, 2-hydroxyethyl, 2-(loweralkoxy)ethyl, and vinyl;
- n is 0, 1, or 2;
- Z is selected from the group consisting of ethylene, vinylene, and ethynylene;
- R.sup.2 is hydrogen or methyl;
- R.sup.3 is hydrogen;
- R.sup.4 is hydrogen or methyl;
- R.sup.5, taken together as a single substituent with R.sup.2 and the carbon chain joining R.sup.2 and R.sup.5, is a carbocyclic ring with from 5-9 members.
6 more elements
Dependencies are inferred from the claim text.