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US 4,066,665 AGranted
2-Alkylamino-.alpha.-phenyl-1-cyclohexene-1-methyleneimine, its salts and preparation
AssigneeSandoz Ltd.
InventorWilliam G. Salmond
Life of this patent
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Abstract
Compounds of the formula ##STR1## wherein R and R.sup.o are lower alkyl, R' is optionally substituted phenyl or 2-thienyl and n is 0 to 2, and their salt forms, are prepared by reacting a compound of the formula: ##STR2## with an aromatic nitrile and strong base, and quenching with water when the free base form is desired, said first mentioned compounds being intermediates for quinazolinones.
Claims10
A compound of the formula:
- ##STR14## wherein R.degree. is alkyl of 1 to 3 carbon atoms,
- n is 0, 1 or 2,
- R is alkyl of 1 to 5 carbon atoms, and
- R' is a group of the formula ##STR15## in which Y and Y' are independently hydrogen, alkyl of 1 to 2 carbon atoms, alkoxy of 1 or 2 carbon atoms, fluoro or chloro or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a group of the formula ##STR16## in which Y" is hydrogen, fluoro, chloro, or alkyl of 1 to 3 carbon atoms.
1 more element
A solution of a salt of the formula:
- ##STR17## wherein R.degree. is alkyl of 1 to 3 carbon atoms,
- n is 0, 1 or 2,
- R is alkyl of 1 to 5 carbon atoms,
- R' is a group of the formula ##STR18## in which Y and Y' are independently hydrogen, alkyl of 1 to 2 carbon atoms, alkoxy of 1 or 2 carbon atoms, fluoro or chloro or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a group of the formula ##STR19## in which Y" is hydrogen, fluoro, chloro or alkyl of 1 to 3 carbon atoms, and is magnesium or an alkali metal.
1 more element
A process for producing a compound of claim 1 which comprises reacting a cyclohexylidine of the formula:
- ##STR20##
- in which R, R.degree. and n are defined in claim 9 with:
- 1. a metal-containing base selected from the group consisting of methyl magnesium iodide and an alkali metal salt of a secondary amine;
- and 2 a compound of the formula:
- R' -- C .tbd. N
- in which R' is as defined in claim 9, in an inert solvent to form a solution of the Salt A:
- ##STR21## in which R, R.degree., R' and n are as defined in claim 9, and X is magnesium or an alkali metal corresponding to the metal in the base, and quenching said solution with water.
4 more elements
Dependencies are inferred from the claim text.