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US 4,066,640 AGranted
Methampicillin Lysinate and its method of manufacture
OwnerYoung Sul Kiminventor
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Abstract
Water soluble Methampicillin Lysinate is disclosed along with a method of making the compound. The compound of the invention has superior stability and, because of its greater solubility, has a high rate of absorption into the gastrointestinal tract. Methampicillin Lysinate is prepared by converting ampicillim to methylene-ampicillin which is reacted with L-Lysine to produce the compound of the invention.
Claims1
A process for preparing Methampicillin Lysinate having the formula:
- ##STR3## wherein M is selected from the group consisting of hydrogen, sodium, potassium, calcium and aluminum, which comprises the steps of:
- a. solubilizing ampicillin by converting ampicillin to a water saluble salt;
- b. reacting said water soluble salt of ampicillin with a solution of formaldehyde and formalin to produce methylene ampicillin;
- c. reacting L-Lysine with said methylene ampicillin in acid solution to obtain Methampicillin Lysinate.
1 more element
Dependencies are inferred from the claim text.