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US 4,066,634 AGranted
Purification of synthetic somatostatin
AssigneeAmerican Home Products Corporation
InventorsWilliam H. McGregor, Joseph J. Dougherty
Life of this patent
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Abstract
High speed liquid chromatography of synthetically produced somatostatin yields somatostatin free from structural artifacts.
Claims2
A process for producing chromatographically pure somatostatin which comprises
- a. passing an aqueous solution of impure, synthetically produced somatostatin through a weakly acidic ion exchange resin containing ammonium carboxylate functional groups, with an ammonium hydroxide-ammonium acetate eluant in a volume/volume ratio of 1 to 9 :
- 1 and
- b. collecting the somatostatin containing fraction of eluate.
Dependencies are inferred from the claim text.