2,2-Difluoro-13,14-dihydro-PGA.sub.1 analogs
AssigneeThe Upjohn Company
InventorUdo F. Axen
Life of this patent
Estimating the term…
Abstract
2,2-Difluoro prostaglandin E, F.sub..alpha., F.sub..beta., A, and B analogs are disclosed with intermediates and with processes for making them. These compounds differ from the prostaglandins in that they have two fluoro atoms at the C-2 position in place of the two hydrogen atoms at C-2 in the prostaglandins. These compounds are useful for a variety of pharmacological purposes, including antiulcer, inhibition of platelet aggregation, increase in nasal patency, labor induction at term, and wound healing.
Claims18
A compound of the formula ##STR1## or a mixture comprising that compound and the enantiomer thereof, WHEREIN G IS 2 TO 4, INCLUSIVE;
- Wherein M.sub.1 is ##STR2## ##STR3## wherein R.sub.7 and R.sub.8 are hydrogen or methyl, with the proviso that one of R.sub.7 or R.sub.8 is methyl only when the other is hydrogen;
- WHEREIN M IS 2 TO 4, INCLUSIVE;
- Wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro, alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation, ##STR4## WHEREIN R.sub.5 is hydrogen, methyl, or fluoro with the proviso that R.sub.5 is fluoro only when R.sub.7 and R.sub.8 are both hydrogen, and with the proviso that R.sub.5 is hydrogen only when either one of R.sub.7 and R.sub.8 is methyl.
Dependencies are inferred from the claim text.