7-(.alpha.-Sulfoacylamido)cephalosporins

Abstract

Novel cephalosporins of the formula, ##STR1## wherein R is a hydrogen atom or an alkyl, aryl or thienyl group, and R' is a group which constitutes together with the adjacent nitrogen atom a 5- or 6-membered ring containing 1 or 2 nitrogen atoms, which are effective particularly against Pseudomonas aeruginosa as well as against other Gram negative and positive microorganisms, for example, N-[7-(.alpha.-sulfophenylacetamido)ceph-3-em-3-ylmethyl] pyridinium 4-carboxylate, N-[7-(.alpha.-sulfo-3'-thienylacetamido)ceph-3-em-3-ylmethyl] pyridinium-4-carboxylate, and their pharmaceutically acceptable salts thereof. Sodium salt of the former is prepared by, e.g. reacting sodium 7-(.alpha.-sulfophenylacetamido) cephalosporanate with pyridine in water.

Dependencies are inferred from the claim text.