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US 4,065,616 AGranted
Processes for production of a 1-N-(.alpha.-hydroxy-.PHI.-amino alkanoyl)-3-deoxy-5-O-pentafuranosyl neamine and new compounds produced by the same processes
AssigneeZaidan Hojin Biseibutsu Kagaku Kenkyu Kai
InventorsHamao Umezawa, Sumio Umezawa, Tsutomu Tsuchiya, Isamu Watanabe
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Abstract
This invention relates to new processes for the production of a 1-N-(.alpha.-hydroxy-.omega.-aminoalkanoyl)-3'-deoxy-5-O-pentofuranosylnea mine, including 3'-deoxybutirosins A and B, as a semi-synthetic antibiotic. This invention further relates to new and useful semi-synthetic antibiotics which are produced by the above new processes.
Claims2
A compound of the formula (I'):
- ##STR69## wherein E is .beta.-D-xylofuranosyl group, .alpha.-L-arabinofuranosyl group or 5-amino-5-deoxy-.beta.-D-xylofuranosyl group, and n is an integer of 1 or 2, provided that E is .beta.-D-xylofuranosyl group when n is 1 and provided that E is .alpha.-L-arabinofuranosyl or 5amino-5-deoxy-.beta.-D-xylofuranosyl group when n is 2, or a pharmaceutically acceptable acid-addition salt thereof.
A compound which is 1-N-((RS)-3-amino-2-hydroxypropionyl)-3'-deoxy-5-P-.beta.-xylofuranosylnea mine;
- 1-n-((S)-3-amino-2-hydroxypropyonyl)-3'-deoxy-5-O-.beta.-D-xylofuranosylnea mine;
- 1-N-((S)-4-amino-2-hydroxybutyryl)-3'-deoxy-5-0-.alpha.-L-arabinofuranosyln eamine;
- or
- 1-N-((S)-4-amino-2-hydroxybutyryl)-5-O-(5-amino-5-deoxy-.beta.-D-xylofurano syl)-3'-deoxyneamine.
1 more element
Dependencies are inferred from the claim text.