Deoxyaminoglycoside antibiotic derivatives
AssigneeTakeda Chemical Industries, Ltd.
InventorsSatoshi Horii, Yukihiko Kameda, Nariakira Mizokami
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Abstract
A new deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups other than the amino group at the 1-position of the deoxystreptamine moiety are formylated is obtained in a high yield by treating a deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups are formylated with a basic substance. The new derivatives are very important for production of 1-N-modified deoxystreptamine-containing aminoglycoside antibiotics.
Claims10
A compound in which all the amino groups other than the amino group at the 1-position on the deoxystreptamine moiety of an aminoglycoside antibiotic selected from the group consisting of xylostasin, ribostamycin, neomycin-group antibiotic, paromomycin-group antibiotic, kanamycin-group antibiotic, 3'-deoxy and 3',4'-dideoxyderivatives of these antibiotics, gentamicin-group antibiotic and lividomycin-group antibiotic are formylated and the amino group at the 1-position is unsubstituted.
3'-deoxybutirosin A.
3'-deoxybutirosin B.
Dependencies are inferred from the claim text.