Amino acids and esters thereof useful as antihypertensive agents
AssigneeMerck & Co., Inc.
InventorsJoseph George Atkinson, Clarence Stanley Rooney, Yves Girard, Edward L. Engelhardt
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Abstract
A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.
Claims14
A compound of the formula ##STR10## wherein R.sup.1 and R.sup.2 are hydrogen or lower alkyl and R.sup.3 is a substituted benzene ring of the formula ##STR11## wherein Y.sub.1 is hydrogen, cyanoamino, carboxyl, cyano, thiocarbamoyl, aminomethyl, guanidino, hydroxy, methanesulfonamido, nitro, amino, methanesulfonyloxy, carboxymethoxy, or methoxy and Y.sub.2 is a substituted or unsubstituted 5-membered heterocyclic ring containing one or more nitrogen atoms.
Dependencies are inferred from the claim text.