Antiviral 5-(substituted benzal) hydantoins
AssigneesCanada Packers Limited, The Institute of Microbiology and Hygiene of the University of Montreal
InventorsKekhusroo R. Bharucha, Djordje Ajdukovic, Vytautas Pavilanis, Heinrich Maria Schrenk
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Abstract
A method of treating a virus infection caused by an enterovirus of the Pina group which comprises administering to a mammal susceptible to or infected with said virus an effective amount of a compound of the formula: ##STR1## wherein: R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, hydroxy, alkoxy of 1 to 4 carbon atoms, acyloxy of 1 to 4 carbon atoms, halo, or nitro, or R.sub.2 and R.sub.3 together form -OCH.sub.2 O-; or the corresponding acylated derivatives wherein there are one or more acyl groups in the hydantoin moiety and each acyl group contains from 1 to 20 carbon atoms.
Claims18
A method of treating a virus infection caused by an entervirus selected from the group consisting of poliomyelitis, coxsackie and echo viruses which comprises administering to a mammal in need of said treatment a non-toxic amount effective to treat said virus of said group of a compound of the formula;
- ##STR3## wherein:
- formula I includes individual geometrical isomers or mixtures thereof,
- R.sub.1 is hydrogen or alkoxy of 1-4 carbon atoms, R.sub.2, and R.sub.3 are each alkoxy of 1 to 4 carbon atoms,
- and R.sub.4 and R.sub.5 are each hydrogen or alkanoyl containing from 1 to 20 carbon atoms with the proviso that one of R.sub.4 and R.sub.5 is alkanoyl.
Dependencies are inferred from the claim text.