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US 4,065,568 AGranted
3-Carbo(lower alkoxy)hydrazinoindazoles
AssigneeBayer Aktiengesellschaft
InventorsKarl Heinrich Mayer, Friedrich Hoffmeister, Wolfgang Wuttke
Life of this patent
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Abstract
3-Hydrazinoindazoles acylated with a carbo(lower alkoxy) group in the 3-position and further being optionally substituted in one or more of the 4-, 5-, 6- and/or 7-positions are analgesic, anti-inflammatory and antipyretic agents. The compounds, of which 3-carbomethoxyhydrazino-6-chloroindazole is a typical embodiment, are prepared through treatment of the appropriate 3-hydrazinoindazole with a derivative of carbonic acid.
Claims12
A compound selected from the group consisting of a 3-carbo(lower alkoxy)hydrazinoindazole of the formula:
- ##STR8## wherein R.sup.1 is lower alkyl;
- and each of R.sup.2', R.sup.2'' and R.sup.2''' is selected, independently of the others, from the group consisting of hydrogen, lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, nitro, amino, lower alkylamino of 1 to 6 carbon atoms, di(lower alkyl of 1 to 6 carbon atoms)amino, lower alkanoylamino of 1 to 6 carbon atoms, carbo(lower alkoxy of 1 to 6 carbon atoms)amino, halo, trifluoromethyl, cyano and carbo(lower alkoxy of 1 to 6 carbon atoms),
- and the pharmaceutically acceptable nontoxic salts thereof.
Dependencies are inferred from the claim text.