Substituted nitroimidazolyl thiadiazoles and oxadiazoles as antibacterial agents and growth promoting compounds
AssigneeAmerican Cyanamid Company
InventorsGerald Berkelhammer, Goro Asato
Life of this patent
Estimating the term…
Abstract
The use of substituted nitroimidazolyl-thiadiazoles and oxadiazoles are described along with methods of administeration of the same. These compounds are active in enhancing the growth rate of warm-blooded animals and in controlling the growth of pathogenic microorganisms such as bacteria.
Claims11
A method of controlling the growth of bacteria in warm-blooded animals which comprises orally administering to said animals an antibacterially effective amount of a nitroimidazole of the formula:
- ##STR4## wherein R is selected from the group consisting of lower alkyl, hydroxy lower alkyl, lower alkanoyloxy lower alkyl and benzyl;
- and R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, hydroxy lower alkyl, lower alkoxy lower alkyl, cyclohexyl, formyl, lower alkanoyl, monochlorolower alkanlyl, dichloro lower alkanoyl, lower alkyl aminolower alkyl;
- ##STR5## taken together is --N.dbd.CHN (lower alkyl).sub.2 ;
- and physiologically acceptable salts thereof.
A therapeutic composition useful for the control of bacterial infections in warm-blooded animals comprising an antibacterially effective amount of a nitroimidazole of the formula:
- ##STR6## wherein R is selected from the group consisting of lower alkyl, hydroxy lower alkyl;
- lower alkanoyloxy lower alkyl and benzyl;
- and R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, hydroxy lower alkyl, lower alkoxy lower alkyl, cyclohexyl, formyl, lower alkanoyl, monochlorolower alkanoyl, dichloro lower alkanoyl, lower alkyl aminolower alkyl;
- ##STR7## taken together is --N.dbd.CHN (lower alkyl).sub.2 ;
- and physiologically acceptable salts thereof and an edible carrier.
Dependencies are inferred from the claim text.