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US 4,065,565 AGranted
Acylhydrazones and anti-psychotic compositions thereof
AssigneeSumitomo Chemical Company, Limited
InventorsKikuo Sasajima, Keiichi Ono, Masaru Nakao, Isamu Maruyama, Shigenari Katayama, Shigeho Inaba, Hisao Yamamoto
Life of this patent
Estimating the term…
Abstract
Acylhydrazone compounds having excellent pyschotropic activity which are represented by the formula: ##STR1## wherein Z is selected from the groups having the formulas: ##STR2## wherein n is an integer of from 0 to 2 and R.sup.1 -R.sup.12 are as defined hereinbelow.
Claims9
A compound of the formula:
- ##STR11## wherein R.sup.1 is halogen, R.sup.2 is hydrogen, halogen or benzoylamino of which the benzoyl is optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkanoyl, cyclopropylcarbonyl, cyclohexylcarbonyl, lower alkenoyl, phenyl(lower)alkanoyl, halo(lower)alkanoyl, amino(lower)alkanoyl, phenoxy(lower)-alkanoyl, lower alkylamino(lower)alkanoyl, lower alkoxy(lower)alkanoyl, or phenyl(lower)alkenoyl, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is benzoyl, lower alkanoyl, phenyl(lower)alkanoyl, cyclopropylcarbonyl, cyclohexylcarbonyl or phenoxy(lower)alkanoyl and Z is a group having the formula:
- ##STR12## wherein R.sup.5 is hydrogen, hydroxyl or benzoyloxy optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkanoyl, cyclopropylcarbonyl, cyclohexylcarbonyl, lower alkenoyl, phenyl(lower)alkanoyl, halo(lower)alkanoyl, amino(lower)alkanoyl, phenoxy(lower)alkanoyl, lower alkylamino(lower)alkanoyl, lower alkoxy(lower)alkanoyl, or phenyl(lower)alkenoyl, and R.sup.6 is hydrogen, phenyl or benzyl, said phenyl or benzyl being optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl on the benzene ring;
- ##STR13## wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.7 is hydrogen or lower alkyl and R.sup.8 and R.sup.9 are each hydrogen, halogen or lower alkyl;
- ##STR14## wherein R.sup.10 is hydrogen or lower alkyl and R.sup.11 is hydrogen, halogen, lower alkyl or lower alkoxy;
- or ##STR15## wherein R.sup.12 is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl and n is an integer of from 0 to 2, or a pharmaceutically acceptable salt thereof.
2 more elements
A compound of the formula:
- ##STR16## wherein R.sup.2 is hydrogen or halogen, R.sup.4 is benzoyl, lower alkanoyl, phenyl(lower)alkanoyl, cyclopropylcarbonyl, cyclohexylcarbonyl or phenoxy(lower)alkanoyl and Z is a group having the formula:
- ##STR17## wherein R.sup.5 is hydrogen, hydroxyl or benzoyloxy optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkanoyl, cyclopropylcarbonyl, cyclohexylcarbonyl, lower alkenoyl, phenyl(lower)alkanoyl, halo(lower)alkanoyl, amino(lower)alkanoyl, phenoxy(lower)alkanoyl, lower alkylamino(lower)alkanoyl, lower alkoxy(lower)alkanoyl, or phenyl(lower)alkenoyl, and R.sup.6 is hydrogen, phenyl or benzyl, said phenyl or benzyl being optionally substituted with one or two substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl on the benzene ring;
- ##STR18## wherein the dotted line indicates the optional presence of an additional single bond linkage, R.sup.7 is hydrogen or lower alkyl and R.sup.8 and R.sup.9 are each hydrogen, halogen or lower alkyl;
- ##STR19## wherein R.sup.10 is hydrogen or lower alkyl and R.sup.11 is hydrogen, halogen, lower alkyl or lower alkoxy;
- or ##STR20## wherein R.sup.12 is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl and n is an integer of from 0 to 2, or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.