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US 4,065,554 AGranted
X-ray contrast media
AssigneeLaboratoires Andre Guerbet
InventorsGuy Tilly, Michel Jean Charles Hardouin, Jean Lautrou
Life of this patent
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Abstract
The present invention provides new iodo benzene derivatives which have at least two benzene nuclei and one carboxylic group. These derivatives possess a low toxicity and may be used as X-ray contrast media.
Claims4
An iodobenzene derivative selected from the group consisting of a compound of formula ##STR96## in which:
- R.sub.1 is selected from the group consisting of a radical having the formula ##STR97## R.sub.5 and R.sub.6 being each selected from the group consisting of hydrogen, lower alkyl, lower hydroxyalkyl and lower alkanoyloxyalkyl and a radical of the formula ##STR98## R.sub.7 being lower alkanoyl and R.sub.8 being selected from the group consisting of hydrogen, lower alkyl and lower hydroxyalkyl,
- R.sub.2 is selected from the group consisting of a radical having the formula ##STR99## in which R.sub.9 and R.sub.10 have the meanings given for R.sub.5 and R.sub.6, and a radical of the formula ##STR100## in which R.sub.11 has the meaning given for R.sub.7 or represents hydrogen and R.sub.12 has the meaning given for R.sub.8,
- at least one of the radicals R.sub.1 and R.sub.2 being of ##STR101## R.sub.4 is selected from the group consisting of hydrogen, lower alkyl and lower hydroxyalkyl,
- R.sub.15 is selected from the group consisting of hydrogen, lower alkanoyl and polyhydroxy lower alkanoyl,
- R.sub.16 is selected from the group consisting of hydrogen, lower alkyl, lower hydroxyalkyl and lower alkanoyl,
- a is 0 or 1
- n is an integer from 1 to 5
- b is 1 or 2
- and the different R.sub.2, R.sub.4 and n which exist when b = 2 may have the same or different meanings,
- a lower alkyl ester thereof and a salt with a pharmaceutically acceptable base.
7 more elements
Dependencies are inferred from the claim text.