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US 4,065,553 AGranted
X-Ray contrast media
AssigneeLaboratoires Andre Guerbet
InventorsGuy Tilly, Michel Jean Charles Hardouin, Jean Lautrou
Life of this patent
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Abstract
The present invention provides new iodo benzene derivatives which have at least two benzene nuclei and one carboxylic group. These derivatives possess a low toxicity and may be used as X-ray contrast media.
Claims4
An iodobenzene derivative selected from the group consisting of a compound of formula ##STR60## in which:
- R.sub.1 is selected from the group consisting of hydrogen and a radical having the formula ##STR61## R.sub.5 and R.sub.6 being each selected from the group consisting of hydrogen, lower alkyl, lower hydroxyalkyl and lower alkanoyl-oxyalkyl, is selected from the group consisting of hydrogen and a radical having the formula ##STR62## in which R.sub.9 and R.sub.10 have the meanings given for R.sub.5 and R.sub.6, at least one of the radicals R.sub.1 and R.sub.2 being hydrogen,
- R.sub.4 is selected from the group consisting of hydrogen, lower alkyl and lower hydroxyalkyl,
- R.sub.15 is selected from the group consisting of hydrogen, lower alkanoyl and polyhydroxy lower alkanoyl,
- R.sub.16 is selected from the group consisting od hydrogen, lower alkyl, lower hydroxyalkyl and lower alkanoyl,
- a is 0 or 1
- n is an integer from 1 to 5
- b is 1 or 2
- and the different R.sub.2, R.sub.4 and n which exist when b = 2 may have the same or different meanings, a lower alkyl ester thereof and a salt with a pharmaceutically acceptable base.
5 more elements
Dependencies are inferred from the claim text.