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US 4,065,464 AGranted
Process for the preparation of substituted trichloroacetamidine derivatives
AssigneeMerck & Co., Inc.
InventorsGeorge H. Denny, Walfred S. Saari
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Abstract
Substituted trichloroacetamidine derivatives are prepared by reacting trichloroacetamidine with an appropriately substituted compound also substituted with a suitable leaving group. The leaving groups are halogen, quaternary or tertiary amines, methanesulfonate, toluenesulfonate, and the like.
Claims5
A process for the preparation of a compound having the formula:
- ##STR2## wherein R is 3-indolylmethyl, which comprises treating with trichloroacetamidine a compound having the formula:
- R-G
- wherein R is as previously defined and G is a leaving group selected from a halide, an amine substituted with two groups selected from loweralkyl or aromatic hydrocarbon and loweralkyl quaternary derivatives thereof;
- pyridyl, loweralkylsulfonate and an aromatic sulfonate at reflux temperature for from 5 minutes to 6 hours.
1 more element
Dependencies are inferred from the claim text.