4,5,6,7-Tetrahydro-thieno[3,2-c]-pyridine derivatives and process for their preparation
AssigneeParcor
InventorsAlain Heymes, Jean-Pierre Maffrand
Life of this patent
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Abstract
This invention relates to 4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine derivatives, having the formula: ##STR1## in which R.sub.1 is hydrogen or alkyl having 1-6 carbon atoms; R.sub.2 is hydrogen, an alkyl group having 1-6 carbon atoms or a phenyl or benzyl radical; R.sub.3 represents an alkyl group having 1-6 carbon atoms or a benzyl radical, and their pharmaceutically acceptable acid addition salts. Said derivatives have an anti-inflammatory and antalgic activity.
Claims6
A compound selected from the group consisting of 4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine derivatives having the formula:
- ##STR6## in which R.sub.1 is selected from the group consisting of hydrogen and the alkyl radicals having 1-6 carbon atoms;
- R.sub.2 is selected from the group consisting of hydrogen, an alkyl group having 1-6 carbon atoms, the phenyl radical, and the benzyl radical;
- R.sub.3 is selected from the group consisting of an alkyl group having 1-6 carbon atoms, and the benzyl radical;
- and the pharmaceutically acceptable acid addition salts of said derivatives.
Process for the preparation of a compound selected from the group consisting of 4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine derivatives having the formula:
- ##STR7## in which R.sub.1 is selected from the group consisting of hydrogen and the alkyl radicals having 1-6 carbon atoms;
- R.sub.2 is selected from the group consisting of hydrogen, an alkyl group having 1-6 carbon atoms, the phenyl radical, and the benzyl radical;
- R.sub.3 is selected from the group consisting of an alkyl group having 1-6 carbon atoms, and the benzyl radical;
- and the pharmaceutically acceptable acid addition salts of said derivatives, comprising condensing a derivative of the formula:
- ##STR8## in which R.sub.1, R.sub.2 and R.sub.3 have the above-defined meanings, with formaldehyde, to give an imine of the formula:
- ##STR9## and subsequently cyclizing said imine (III) to the derivative of the formula (I).
Dependencies are inferred from the claim text.