Process for preparing 2-guanidinomethyl-perhydroazocine-sulfate
AssigneeEgyt Gyogyszervegyeszeti Gyar
InventorsJozsef Rakoczi, Ivan Beck, Csaba Kiss, Imre Horvath, Miklos Nemes
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Abstract
The invention relates to a novel process for preparing 2-guanidinomethyl-perhydroazocine-sulfate of formula I ##STR1## comprising the steps of catalytically reducing the 2-nitromethylene-perhydroazocine of formula IV ##STR2## in solution in acetone at a temperature of 20.degree. to 50.degree. C, treating the separated reaction product with an aqueous mineral acid and then reacting it with S-methyl-isothiocarbamid-sulfate. The process gives the desired end-product of formula I also on industrial scales.
Claims3
A novel process for preparing 2-guanidinomethyl-perhydroazocine-sulfate of formula I ##STR7## by catalytical reduction of 2-nitromethylene-perhydroazocine of formula IV ##STR8## and reacting the thus-obtained product with S-methyl-isothiocarbamide-sulfate, characterized in that the 2-nitromethylene-perhydroazocine is hydrogenated in solution in acetone at a temperature of 20 to 50.degree. C, whereafter the separated reaction product is treated with an aqueous mineral acid and then reacted with the S-methyl-isothiocarbamid-sulfate.
Dependencies are inferred from the claim text.