Method for the preparation of D-carbamyl aminoacids and the corresponding D-aminoacids
AssigneeSnamprogetti S.p.A.
InventorsFrancesco Cecere, Giuliano Galli, Gino Della Penna, Bruno Rappuoli
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Abstract
An enzymatic hydrolysis method is disclosed for the preparation of D-carbamyl aminoacids and the corresponding D-aminoacids. The method is based on the use of certain substituted hydantoins as the starting materials and these are hydrolized, in a temperature range from 10.degree. C to 70.degree. C, with hydropyrimidine hydrolase from calf livers. The pH range is from 8 to 9. The method in question is cheaper and more reliable than those of the prior art.
Claims4
A method for the preparation of D-carbamyl aminoacids comprising the steps of subjecting to enzymatic hydrolysis in the presence of a hydropyrimidine hydrolase and a racemic mixture of compounds having the formula:
- ##STR5## wherein X represents --OH, hydrocarbon radicals, halogen, alkoxyl, --NO.sub.2, carboxyls, at a pH between 8 and 9.
A method for the preparation of D-aminoacids which comprises the steps of subjecting to enzymatic hydrolysis in the presence of hydropyrimidine hydrolase from calf liver, a racemic mixture of compounds having the formula:
- ##STR6## wherein X represents --OH, hydrocarbon radicals, halogen, alkoxyl --NO.sub.2 carboxyls, at a pH between 8 and 9 to form D-carbamyl aminoacids and thereafter hydroyzing said D-carbamyl aminoacid to the D-aminoacid by the steps of dissolving said D-carbamyl aminoacid in water to form an aqueous solution and heating said solution to the boiling point to form said D-aminoacid.
Dependencies are inferred from the claim text.