Bis-basic ketones of fluorene and fluorenone
AssigneeRichardson-Merrell Inc.
InventorsRobert W. Fleming, Arthur D. Sill, William L. Albrecht, Stephen W. Horgan
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AssigneeRichardson-Merrell Inc.
InventorsRobert W. Fleming, Arthur D. Sill, William L. Albrecht, Stephen W. Horgan
Estimating the term…
The novel bis-basic ketones of fluorene and fluorenone of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: ##STR1## wherein Z is oxygen or H.sub.2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group ##STR2## wherein R.sup.1 and R.sup.2 are individually hydrogen, (lower)alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or B. the group ##STR3## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R.sup.3 is hydrogen, (lower)alkyl of 1 to about 4 carbon atoms, phenyl, or benzyl and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group ##STR4## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or (lower)alkyl of from 1 to about 4 carbon atoms; or D. the group ##STR5## WHEREIN P IS A WHOLE INTEGER FROM 2 TO 3, AND M IS A WHOLE INTEGER FROM 1 TO 2; OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT OF SAID BASE. These new compounds may be prepared by several different methods which are described.
A compound selected from a base of the formula ##STR30## wherein Z is a member selected from the group consisting of oxygen or H.sub.2 ;
A compound selected from a base of the formula ##STR34## wherein:
A compound selected from a base of the formula ##STR47## wherein:
Dependencies are inferred from the claim text.