Cephalosporins derivatives 7-cyclized .alpha.-amino-3-heterothio
AssigneeBristol-Myers Company
InventorsMurray A. Kaplan, William J. Gottstein, Alphonse P. Granatek
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AssigneeBristol-Myers Company
InventorsMurray A. Kaplan, William J. Gottstein, Alphonse P. Granatek
Estimating the term…
Compounds of the formula ##STR1## wherein A is hydrogen, hydroxy, methyl or methoxy, R.sup.1 is hydrogen, sodium or potassium, R.sup.2 is carboxyl or 2-furyl or an aliphatic, aromatic or heterocyclic radical to which there is also attached a strongly acidic group in the form of its sodium or potassium salt, and R.sup.3 is tetrazol-5-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-2-yl, 1,3,4-oxadiazol-3-yl or 1,2,4-triazol-5-yl, each of such groups being unsubstituted or substituted with one or two lower alkyl groups of one to four carbon atoms are prepared by reacting the appropriate aldehyde with the corresponding amphoteric cephalosporin. Preferred products have the structure ##STR2## in which A is --H or --SO.sub.3 Na.
A compound of the formula ##STR28## wherein A is hydrogen, hydroxy, methyl or methoxy,
A compound of the formula ##STR29## wherein A is hydrogen, hydroxy, methyl or methoxy, and
A compound of the formula ##STR30## wherein R.sup.1 is hydrogen, sodium or potassium.
A compound of the formula ##STR31## wherein A is hydrogen, hydroxy, methyl or methoxy and
A compound of the formula ##STR33## wherein A is hydrogen, hydroxy, methyl or methoxy and
A compound of the formula ##STR35## wherein:
A compound of the formula ##STR37## wherein A is hydrogen, hydroxy, methyl or methoxy and
A compound of the formula ##STR39## wherein A is hydrogen, hydroxy, methyl or methoxy and
Dependencies are inferred from the claim text.