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AssigneeBayer Aktiengesellschaft
InventorsHartmund Wollweber, Ekkehard Niemers, Hans Peter Schulz, Herbert Thomas, Peter Andrews
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A new class of N'-(aminoacylaminophenyl) acetamidines: ##STR1## in which R.sup.1 and R.sup.2 are the same or different and represent hydrogen, alkyl, aryl or the substituted derivatives thereof or, together with the nitrogen atom to which they are attached, an heterocyclic ring; and R.sup.3 is hydrogen, alkyl, aryl, aralkyl, or a heterocyclic moiety including the substituted derivatives thereof. The products have utility as anthelmintics. The products are obtained by treating a suitable amino-acid or a carbonyl-activated amino-acid, with the appropriate N'-(4-aminophenyl)-N,N-dimethylacetamidine. In addition, the products are obtained by treating a suitable N'-(haloacylaminophenylacetamidine with an appropriate amine.
A compound of the formula:
A compound according to caim 1 wherein
An anthelmintic composition useful for treathelminthic infections in humans and animals which comprises an anthlemintically effective amount of a compound of the formula ##STR48## or a pharmaceutically acceptable non-toxic salt thereof wherein R.sup.1 and R.sup.2 are the same or different and each is hydrogen, or lower alkyl unsubstituted or substituted by lower alkoxy;
A method for treating helminthic infections in humans and animals which comprises administering to a human or animal in need thereof an anthelmintically effective amount of a compound of the formula ##STR61## or a pharmaceutically acceptable non-toxic salt thereof wherein R.sup.1 and R.sup.2 are the same or different and each is hydrogen or lower alkyl unsubstituted or substituted by lower alkoxy;
Dependencies are inferred from the claim text.