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US 4,064,252 AGranted
Substituted N-(carboxymethyl)-3-aminopropan-2-ol derivatives
AssigneeNippon Shinyaku Co., Ltd.
InventorsHiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Maehara, Katsuhide Saito, Takayuki Ozaki
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Abstract
New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.
Claims9
A compound of the formula:
- ##STR26## wherein Z is oxygen or sulfur;
- X is hydrogen, halogeno, lower alkyl, lower alkoxy, carboxy, carbo(lower alkoxy) or carbamoyl;
- Y, when Z is sulfur, is hydrogen, halogeno or lower alkyl, or, when Z is oxygen, hydrogen, halogeno, lower alkyl, lower alkoxy, hydroxy, carboxy, or carbo(lower alkoxy);
- R.sub.1 is hydroxy or lower alkoxy, unsubstituted or substituted by hydroxy or lower alkoxy;
- and
- R.sub.2 is nicotinoyl,
- and the pharmaceutically acceptable salts thereof.
4 more elements
Dependencies are inferred from the claim text.