Organic compounds
AssigneeSandoz Ltd.
InventorDieter Sorg
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Abstract
The present invention concerns novel 2-(1-piperazinyl)-thiazole derivatives of the formula, ##STR1## wherein R.sub.1 is alkyl or cycloalkly, R.sub.2 is hydrogen or alkyl, and R.sub.3 is benzyl, alkoxyalkyl or alkoxycarbonyl, or alkyl, alkenyl, alkanoyl or hydroxyalkyl, or acyloxyalkyl, Useful as vigilance increasing agents, anorexigenic agents and anti-migraine agents.
Claims41
A compound of the formula ##STR11## where R.sub.1 is t-butyl or cycloalkyl of 3 to 8 carbon atoms,
- R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms,
- and
- R.sub.3 is benzyl, alkoxyalkyl or alkoxycarbonyl having at most 6 carbon atoms in the aggregate thereof, or alkyl, alkenyl, alkanoyl or hydroxyalkyl having at most 4 carbon atoms, or alkanoyloxy alkyl having at most 8 carbon atoms in the aggregate thereof
- or a pharmaceutically acceptable acid addition salt thereof.
The compound which is 2-(4-methyl-1-piperazinyl)-4-tert.butyl-thiazole.
The compound which is 2-(4-methyl-1-piperazinyl)-4-sec.butyl-thiazole.
The compound which is 2-(4-methyl-1-piperazinyl)-4-isobutyl-thiazole.
The compound which is 2-(4-methyl-1-piperazinyl)-4-n-butyl-thiazole.
The compound which is 2-(4-methyl-1-piperazinyl)-4-cyclopentyl-thiazole.
Dependencies are inferred from the claim text.