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US 4,064,242 AGranted
7-Acylamino-3-[1-(2,3-dihydroxypropyl)tetrazole-5-ylthiomethyl]-3-ceph em-4-carboxylic acids
AssigneeSmithKline Corporation
InventorStanley J. Schmidt
Life of this patent
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Abstract
New semisynthetic cephalosporins characterized by having structures with a 1-dihydroxypropyltetrazole-5-ylthiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-[1-(2,3-dihyroxypropyl)tetrazole-5-ylthiomethyl]-3-cephe m-4-carboxylic and 7-(D-.alpha.-phenyl-.alpha.-aminoacetamido)-3-[1-(2,3-dihydroxypropyl)-tet razole-5-ylthiomethyl]-3-cephem-4-carboxylic acid.
Claims6
A chemical compound of the formula:
- ##STR3## in which:
- X is thienyl, furyl, phenyl or phenyl monosubstituted with hydroxy, hydroxymethyl, formamido or ureido;
- and
- A is NH.sub.2, OH, COOH, SO.sub.3 H, formyloxy or, when the .alpha.-C-hydrogen is absent, methoxyimino;
- and the nontoxic, pharmaceutically acceptable alkali metal salts of said chemical compound.
2 more elements
Dependencies are inferred from the claim text.