7[(Carboxyoxiran-3-carboxamido)phenylacetamido]cephalosporin derivatives

A compound of the formula:

• ##STR14## and the pharmaceutically acceptable base salts thereof, wherein R.sup.1 is a member selected from the group consisting of phenyl, thienyl and 2-furyl, and mono substituted phenyl wherein the substituent is chosen from the group consisting of halogen, hydroxy, lower alkyl, lower alkoxy and trifluoromethyl;
• R is hydroxy, and R.sup.2 is a member selected from the group consisting of pyrimidin-2-ylthio, 4,6-dimethylpyrimidin-2-ylthio, 4,5-dimethylthiazol-2-ylthio, 1,3,5-triazin-2-ylthio, 2-methyl-1,3,4-thiadiazol-5-ylthio, 2-methyl-1,3,4-oxadiazol-5-ylthio and 1-substituted-1,2,3,4-tetrazol-5-ylthio wherein the 1-substituent is chosen from the group consisting of lower alkyl, benzyl, phenyl, chlorophenyl and anisyl;
• R.sup.3 is a member selected from the group consisting of carboxy, COOR.sup.6 wherein R.sup.6 is chosen from the group consisting of lower alkyl, 5-indanyl, naphthyl, phenyl and mono substituted phenyl wherein the substituent is chosen from the group consisting of halogen, lower alkyl, lower alkoxy and trifluoromethyl, and CONR.sup.7 R.sup.8 wherein R.sup.7 and R.sup.8 are each chosen from the group consisting of hydrogen, lower alkyl and cycloalkyl having from three to six carbon atoms;
• R.sup.4 and R.sup.5 are each a member selected from the group consisting of hydrogen and lower alkyl, and X is a direct carbon-carbon link.