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US 4,064,235 AGranted
Dopamine derivative compounds, preparation thereof and medicine containing same
AssigneeEisai Co., Ltd.
InventorsNoboru Yanaihara, Toshiji Igarashi, Youichi Kunii
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Abstract
A novel dopamine derivative compound having the following general formula and pharmacologically acceptable acid addition salt thereof: ##STR1## wherein X stands for a di- or tri-peptide residue derived from alanine, glycine, glutamine, isoleucine, lysine, leucine, tyrosine proline or valine, having an excellent activity of increasing the renal blood flow are provided.
Claims14
A compound having the formula:
- ##STR8## wherein X is a di- or tri-peptide residue derived from alanine, glycine, glutamine, isoleucine, lysine, leucine, tyrosine, proline or valine, or a pharmacologically acceptable acid addition salt thereof.
A method of increasing the renal blood flow rate in a subject requiring such treament, which comprises:
- administering to such subject a therapeutically effective amount of a compound having the formula:
- ##STR14## wherein X is a di- or tri-peptide residue derived from alanine, glycine, glutamine, isoleucine, lysine, leucine, tyrosine, proline or valine,
- or a pharmacologically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.