Methods and pharmaceutical preparation for the treatment of hypercholesterolemia
AssigneeBristol-Myers Company
InventorAlan N. Howard
Life of this patent
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Abstract
A composition for treatment of hypercholesterolemia contains clofibrate or a clofibrate derivative, a magnesium or aluminum ion contributing compound which forms substantially insoluble metal bile acid salts and, optionally, a basic anion exchange resin. The composition components combine to give synergistic effect.
Claims16
A pharmaceutical composition for use in the treatment per os of hypercholesterolemia, which comprises a hypocholesteremic effective amount of
- a. a compound selected from p-chlorophenoxyisobutyric acid, the methyl, ethyl, propyl or butyl ester thereof or a sodium, potassium, calcium, magnesium, aluminum, zinc, bismuth or iron salt thereof, and
- b. an ingestible non-toxic aluminum or magnesium salt capable of dissolution in human gastrointestinal juices, the total amount of non-toxic metal being from 3.2 to 90 equivalents per mole of p-chlorophenoxyisobutyric acid or ester or salt thereof.
A method for the treatment of hypercholesterolemia, in which there is administered to the patient per os a hypocholesteremic effective dose of a pharmaceutical composition comprising
- a. a compound selected from p-chlorophenoxyisobutyric acid, the methyl, ethyl, propyl or butyl ester thereof or a sodium, potassium, calcium, magnesium, aluminum, zinc, bismuth or iron salt thereof, and
- b. an ingestible non-toxic aluminum or magnesium salt capable of dissolution in human gastrointestinal juices, the total amount of non-toxic metal being from 3.2 to 90 equivalents per mole of p-chlorophenoxyisobutyric acid or ester or salt thereof.
Dependencies are inferred from the claim text.