Polyenic macrolide compositions
AssigneeSchmid Laboratories, Inc.
InventorsHarry W. Gordon, Carl P. Schaffner
Life of this patent
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Abstract
A method of increasing the overall effectiveness, including stability and gastrointestinal tolerability, of a polyenic macrolide selected from the class consisting of candicidin, fungimycin, hamycin and mediocidin is described which comprises orally administering the polyenic macrolide with an absorbent material. Compositions containing a polyenic macrolide and a suitable absorbent material preferably in beadlet form are described for use in treating various conditions including prostate hypertrophy, hypercholesterolemia and acne.
Claims14
A composition comprising a capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 milligrams to about 100 milligrams of a polyenic macrolide selected from the class consisting of hamycin and mediocidin and (2) an absorbent material which binds with said polyenic macrolide in a substantially acidic pH environment and loses its affinity for said polyenic macrolide in a substantially neutral pH environment, the ratio of said polyenic macrolide to said absorbent material being about 1 to 2 to about 1 to 8.
A formulation comprising a hard shell capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 to 100 milligrams of mediocidin, and (2) about 50 to about 400 milligrams of calcium carbonate, the ratio of mediocidin to calcium carbonate being no greater than about 1 to 2, said formulation having a pH between about 6.5 and 7.5.
A formulation comprising a hard shell capsule containing a multiplicity of beadlets, said beadlets together comprising (1) about 25 to about 100 milligrams of hamycin, and (2) about 50 to about 400 milligrams of calcium carbonate, the ratio of hamycin to calcium carbonate being no greater than about 1 to 2, said formulation having a pH between about 6.5 and 7.5.
Dependencies are inferred from the claim text.