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US 4,064,228 AGranted
Antigens and immunoassays for morphine and related 3-oxybenzomorphan compounds
AssigneeBiological Developments, Inc.
InventorStanley Joseph Gross
Life of this patent
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Abstract
Antigens capable of generating antibodies specific to morphine and other 3-oxybenzomorphan compounds are prepared by conjugating 3-oxybenzomorphan derivatives with immunogenic carriers employing a linking site on an aryl group of the 3-oxybenzomorphan other than the hydroxyl substituent, so as to produce antibodies specific for the material.
Claims26
An antigen of formula:
- [R--N.dbd.Y--R'--L].sub.n Z,
- where R is a 3-oxybenzomorphan compound;
- Y is selected from the class consisting of N and CH and is connected to a ring carbon atom of an aromatic component of R', R' also having a moiety capable of reacting with a functional group of Z;
- Z is a carrier molecule conferring immunogenicity, the combination of the moiety of R' and the functional group of Z forming the linking group L;
- and n is from 1 to the number of available functional groups on Z in its conjugated state;
- when Y is N, a diazo linkage is present, this diazo linkage being formed by diazotization of a primary amino group on the material from which R' formed;
- when Y is CH, R' is the remaining aromatic component of an aromatic aldehyde, and CH is the condensation residue of the characteristic keto group of the aldehyde, where bonding to R is through an available ring carbon atom of the aromatic ring of the 3-oxybenzomorphan hapten moiety.
4 more elements
An antigen of structure ##STR29## where bonding to R is through an available ring carbon atom of the aromatic ring of the 3-oxybenzomorphan hapten moiety.
Dependencies are inferred from the claim text.