9,10-Seco-steroids
AssigneeHoffmann-La Roche Inc.
InventorsJean-Marie Cassal, Andor Furst, Werner Meier
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Abstract
A process for the preparation of 9,10-seco-steroids of the formula ##STR1## WHEREIN R.sup.1 and R.sup.2 independently are hydrogen, amino, OR.sup.5, OCOR.sup.6 or NHCOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl and R.sup.6 is lower alkyl or phenyl; R.sup.3 is lower alkyl; R.sup.4 is oxo, ##STR2## wherein R.sup.13 is lower alkyl, lower alkoxy -- lower alkylene, tetrahydropyranyl or tetrahydrofuryl, R.sup.14 is lower alkyl or aryl and R.sup.15 and R.sup.16 are lower alkyl or taken together form lower alkylene or arylene, and n is 1 or 2 is disclosed. The 9,10-seco-steroids of this invention are useful intermediates for the preparation of steroids.
Claims10
A compound of the formula ##STR14## wherein R.sup.3 is lower alkyl;
- R.sup.4 is ##STR15## wherein R.sup.13 is lower alkyl;
- R.sup.7 and R.sup.8 are each independently hydrogen, benzyloxy, diphenylmethoxy, triphenylmethoxy or OR.sup.5 wherein R.sup.5 is lower alkyl;
- R.sup.9 is hydrogen;
- and n is 1 or 2.
The compound 17.beta.-tert.-butoxy-3,6-dinitro-9,10-seco-estra-1,3,5(10)-trien-9-one.
The compound 17.beta.-tert.-butoxy-3,6-dinitro-18-methyl-9,10-seco-estra-1,3,5(10)-trie n-9-one.
Dependencies are inferred from the claim text.