Back to results
US 4,064,143 AGranted
Oleandomycin derivatives
AssigneePfizer Inc.
InventorArthur A. Nagel
Life of this patent
Estimating the term…
Abstract
Certain derivatives of the macrolide antibiotic oleandomycin, in which the L-oleandrosyl residue has been replaced by a 2-substituted-3-methoxytetrahydrofuran-5-yl moiety. The compounds of the invention are useful as antibacterial agents.
Claims16
A compound of the formula:
- ##STR5## and the pharmaceutically-acceptable acid-addition salts thereof;
- wherein R.sup.1 and R.sup.2 are each selected from the group consisting of hydrogen, acetyl and propionyl;
- and X is selected from the group consisting of vinyl, ethyl and formyl.
A compound of the formula:
- ##STR6## wherein R.sup.1 and R.sup.2 are each selected from the group consisting of hydrogen, acetyl and propionyl;
- and R.sup.4 is alkyl having from one to five carbon atoms.
A process for the preparation of a compound of the formula ##STR7## which comprises heating a compound of the formula ##STR8## in a dry, hydrocarbon solvent, at a temperature in the range from about 130.degree. C. to about 160.degree. C;
- wherein R.sup.1 and R.sup.2 are each selected from the group consisting of hydrogen, acetyl and propionyl and R.sup.4 is alkyl having from one to five carbon atoms.
Dependencies are inferred from the claim text.