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US 4,064,139 AGranted
Substituted 9,10-dihydroanthracen-9,10-imines
AssigneeMerck & Co., Inc.
InventorsPaul S. Anderson, Marcia E. Christy, Gerald S. Ponticello
Life of this patent
Estimating the term…
Abstract
Substituted 9,10-dihydroanthracen-9,10-imines are disclosed to be minor tranquilizers, anticonvulsnts, muscle relaxants, and to be useful in the treatment of extrapyramidal disorders such as Parkinson's disease; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions.
Claims55
A compound selected from the group consisting of:
- 2-bromo-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 2-methoxy-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 2-chloro-11-propyl-9,10-diethyl-9,10-dihydroanthracen-9,10-imine;
- 2-iodo-11-propyl-9,10-diethyl-9,10-dihydroanthracen-9,10-imine;
- 2-bromo-11-propyl-9,10-diethyl-9,10-dihydroanthracen-9,10-imine;
- 2-chloro-11-cyclopropyl-9,10-diethyl-9,10-dihydroanthracen-9,10-imine;
- 2-iodo-11-cyclopropyl-9,10-diethyl-9,10-dihydroanthracen-9,10-imine;
- 2-bromo-11-cyclopropyl-9,10-diethyl-9,10-dihydroanthracen-9,10-imine;
- 2-chloro-11-(3-hydroxypropyl)-9,10-diethyl-9,10-dihydroanthracen-9,10-imine
- 2-iodo-11-(3-hydroxypropyl)-9,10-diethyl-9,10-dihydroanthracen-9,10-imine;
- 2-bromo-11-(3-hydroxypropyl)-9,10-diethyl-9,10-dihydroanthracen-9,10-imine;
- 9,10-dihydro-2,11-dimethyl-9,10-diethylanthracen-9,10-imine;
- 2-chloro-9,10-dihydro-9,10-diethyl-11-methylanthracen-9,10-imine;
- 9,10-dihydro-1-fluoro-9,10-diethyl-11-methylanthracen-9,10-imine;
- 9,10-dihydro-2-methoxy-9,10-diethyl-11-methylanthracen-9,10-imine;
- 9,10-dihydro-9,10-diethyl-1,11-dimethylanthracen-9,10-imine;
- 9,10-dihydro-2-trifluoromethyl-9,10-diethyl-11-methylanthracen-9,10-imine;
- 9. 10-dihydro-2-fluoro-9,10-diethyl-11-methylanthracen-9,10-imine;
- 2-bromo-9,10-dihydro-9,10-diethyl-11-methylanthracen-9,10-imine;
- 2-cyano-9,10-dihydro-9,10-diethyl-11-methylanthracen-9,10-imine;
- 2-methylthio-9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 1-isopropyl-9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 2-isopropyl-9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 2-(N,N-dimethylsulfamoyl)-9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10 -imine;
- 2-diethoxymethyl-9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 11-benzyl-9-methyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 10-ethyl-9,11-dimethyl-9,10-dihydroanthracen-9,10-imine;
- 11-benzyl-2,9-dimethyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 11-(3-hydroxypropyl)-9-methyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 11-propyl-9-methyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 11-butyl-9-methyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 1-chloro-9,11-dimethyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 11-allyl-9-methyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 11-cyclopropylmethyl-9-methyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 11-(3-dimethylaminopropyl)-9-methyl-10-ethyl-9,10-dihydroanthracen-9,10-imi ne;
- 2-iodo-11-(3-dimethylaminopropyl)-9-methyl-10-ethyl-9,10-dihydroanthracen-9 ,10-imine;
- 2-bromo-11-(3-dimethylaminopropyl)-9-methyl-10-ethyl-9,10-dihydroanthracen- 9,10-imine;
- 9-methyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 10-vinyl-9,11-dimethyl-9,10-dihydroanthracen-9,10-imine;
- 2-methoxy-9,11-dimethyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 2-bromo-9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 2-nitro-9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 2-amino-9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 3,9,11-trimethyl-9,10-dihydroanthracen-9,10-imine;
- 2,9,11-trimethyl-9,10-dihydroanthracen-9,10-imine;
- 2-chloro-9,11-dimethyl-9,10-dihydroanthracen-9,10-imine;
- 9,11-dimethyl-9,10-dihydroanthracen-9,10-imine;
- 9,11-dimethyl-10-ethyl-9,10-dihydroanthracen-9,10-imine;
- 9,10-bis(trifluoromethyl)-11-methyl-9,10-dihydroanthracen-9,10-imine;
- 11-methyl-9,10-dipropyl-9,10-dihydroanthracen-9,10-imine;
- 11-methyl-9-ethyl-10-propyl-9,10-dihydroanthracen-9,10-imine;
- 2-carboxaldehyde-9,10-diethyl-11-methyl-9,10-dihydroanthracen-9,10-imine;
- and
- 9,10,11-triethyl-9,10-dihydroanthracen-9,10-imine.
52 more elements
Dependencies are inferred from the claim text.