Process for the production of 1,2-dihydro-2-oxo-4-methyl-7-acetoacetic acid amido-quinoline
AssigneeLonza Ltd.
InventorErik Herkenrath
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Abstract
A process for producing 1,2-dihydro-2-oxo-4-methyl-7-amino-quinoline by reacting one mole of diketene with one mole of m-phenylene diamine. Also, a process for producing 1,2-dihydro-2-oxo-4-methyl-7-acetoacetic acid amido-quinoline by reacting two moles of diketene with one mole of m-phenylene diamine.
Claims8
The process for producing 1,2-dihydro-2-oxo-4-methyl-7-acetoacetic acid amido-quinoline which comprises the step of reacting diketene with m-phenylene diamine, whereby said 1,2-dihydro-2-oxo-4-methyl-7-acetoacetic acid amido-quinoline results, the molar ratio of diketene to m-phenylene diamine being between 1.77 to 1 and 2.33 to 1 the reaction being conducted (i) in water in the presence of a catalytic amount of acetic acid or (ii) in an inert organic solvent in the presence of a catalytic amount of acetic acid, the reactants being soluble in the organic solvent, or (iii) in glacial acetic acid, the reaction being conducted at a temperature between room temperature and reflux temperature, and the reaction being conducted at atmospheric pressure.
Dependencies are inferred from the claim text.