Process for the production of orotic acid
AssigneeLonza Ltd.
InventorBarry Jackson
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Abstract
A process for the trichloroacetyl of orotic acid which comprises (a) converting trichloroacetyl chloride to .gamma., .gamma., .gamma.-trichloroacetoacetyl chloride with ketene, (b) adding reaction mixture (a) to urea dissolved in a polar organic solvent, e.g., acetic acid, 6-trichloromethyluracil being produced, (c) separating the 6-trichloromethyluracil from reaction mixture (b), and (d) hydrolyzing the 6-trichloromethyluracil to orotic acid.
Claims16
The process for the production of orotic acid, which comprises (a) converting trichloroacetyl chloride to .gamma.,.gamma. ,.gamma. -trichloroacetoacetyl chloride with ketone, (b) adding reaction mixture (a) to urea dissolved in a polar organic solvent, 6-trichloromethyluracil being produced, (c) separating the 6-trichloromethyluracil from reaction mixture (b), (d) hydrolyzing the 6-trichloromethyluracil to the salt of orotic acid at neutral or weakly basic conditions, and (e) treating the salt of orotic acid with a mineral acid, whereby free orotic acid is produced.
6-trichloromethyluracil.
Dependencies are inferred from the claim text.